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Sci. Aging Knowl. Environ., 19 November 2003 NOTEWORTHY ARTICLESConsequence, Not CauseOxidants arise from, but aren't required for, lethal neuron overstimulationR. John Davenport http://sageke.sciencemag.org/cgi/content/full/sageke;2003/46/nw158Key Words: cerebellar granule cells • dihydroethidium • superoxide dismutase mimetic
Abstract: NEW ORLEANS, LOUISIANA--Overloading a microphone can turn a sweet sax solo into a high-pitched squall. Similarly, a flood of the neurotransmitter glutamate--from stroke, brain injury, or neurodegenerative disease--provokes excess neuron firing and causes cells to die (see Nicholls Perspective). Previous studies hinted that reactive oxygen species (ROS) spurred this slaughter, but new research shows that ROS are a byproduct of the process, according to work presented here on 10 November 2003 at the Society for Neuroscience Annual Meeting. The study helps place ROS in the order of events that lead to neuron death. Citation: R. J. Davenport, Consequence, Not Cause. Sci. Aging Knowl. Environ. 2003 (46), nw158 (2003).
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