Sci. Aging Knowl. Environ., 3 December 2003
Vol. 2003, Issue 48, p. nw163
[DOI: 10.1126/sageke.2003.48.nw163]

NOTEWORTHY ARTICLES

Just a Little Bit

A pinch of growth hormone gives young rats an old collection of drug-processing enzymes

R. John Davenport

http://sageke.sciencemag.org/cgi/content/full/2003/48/nw163

Key Words: CYP • isoform • interpulse period • nadir

Abstract: Cholesterol fighters, heart medicine, arthritis pills--as people age, they need more and more medications to battle an escalating number of ailments. But in the elderly, drugs often lose effectiveness or gain toxicity. Changes in the production of drug-deactivating machinery might be partly to blame. A new study shows that nudging growth-hormone concentrations gives young rats an old complement of enzymes.

Citation: R. J. Davenport, Just a Little Bit. Sci. Aging Knowl. Environ. 2003 (48), nw163 (2003).

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