Sci. Aging Knowl. Environ., 3 December 2003
Vol. 2003, Issue 48, p. pe33
[DOI: 10.1126/sageke.2003.48.pe33]


Coronary Artery Disease and the MEF2A Transcription Factor

Eric N. Olson

The author is in the Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA. E-mail: eric.olson{at}

Key Words: MEF2 • coronary artery disease • dominant negative • autosomal dominant

Abstract: Coronary artery disease (CAD) that results from lesions of the vascular wall is a major cause of myocardial infarction (MI) and stroke. A human pedigree with a predisposition to CAD and MI has been shown to harbor a mutation in the MEF2A transcription factor. These findings reveal a new function for this regulator of cardiovascular development and raise intriguing questions about the underlying mechanisms of CAD.

Citation: E. N. Olson, Coronary Artery Disease and the MEF2A Transcription Factor. Sci. Aging Knowl. Environ. 2003 (48), pe33 (2003).

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