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Sci. Aging Knowl. Environ., 3 December 2003
Vol. 2003, Issue 48, p. pe33
[DOI: 10.1126/sageke.2003.48.pe33]

PERSPECTIVES

Coronary Artery Disease and the MEF2A Transcription Factor

Eric N. Olson

The author is in the Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA. E-mail: eric.olson{at}utsouthwestern.edu

http://sageke.sciencemag.org/cgi/content/full/2003/48/pe33

Key Words: MEF2 • coronary artery disease • dominant negative • autosomal dominant

Abstract: Coronary artery disease (CAD) that results from lesions of the vascular wall is a major cause of myocardial infarction (MI) and stroke. A human pedigree with a predisposition to CAD and MI has been shown to harbor a mutation in the MEF2A transcription factor. These findings reveal a new function for this regulator of cardiovascular development and raise intriguing questions about the underlying mechanisms of CAD.

Citation: E. N. Olson, Coronary Artery Disease and the MEF2A Transcription Factor. Sci. Aging Knowl. Environ. 2003 (48), pe33 (2003).

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