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Sci. Aging Knowl. Environ., 3 December 2003
Vol. 2003, Issue 48, p. pe34
[DOI: 10.1126/sageke.2003.48.pe34]

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Does the Road to Muscle Rejuvenation Go Through Notch?

Jeffrey Boone Miller, and Charles P. Emerson Jr.

The authors are at the Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA. E-mail: emersonc{at}bbri.org (C.P.E.)

http://sageke.sciencemag.org/cgi/content/full/2003/48/pe34

Key Words: sarcopenia • muscle repair • Notch • Delta • skeletal muscle • regeneration

Abstract: The capacity of skeletal muscles to repair and regenerate declines during aging in humans, and this decline may lead to muscle loss and frailty. Conboy et al. show that injured muscles of aging mice are defective in Notch signaling, because up-regulation of the Notch ligand, Delta-1, is impaired. Delta-1 promotes proliferation of the satellite cells that repair damaged muscles, and Conboy et al. show that experimental activation of Notch signaling is sufficient to reverse the age-related decline in muscle regenerative capacity. Extension of these important findings to humans could lead to the development of new therapeutic approaches to maintain muscle function during aging.

Citation: J. B. Miller, C. P. Emerson, Does the Road to Muscle Rejuvenation Go Through Notch? Sci. Aging Knowl. Environ. 2003 (48), pe34 (2003).

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Science of Aging Knowledge Environment. ISSN 1539-6150