Sci. Aging Knowl. Environ., 10 December 2003
Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology
Tiago Fleming Outeiro, and Susan Lindquisthttp://sageke.sciencemag.org/cgi/content/abstract/2003/49/or28
Abstract: Science 302, 1772-1775 (2003)
Alpha-synuclein is implicated in several neurodegenerative disorders, such as Parkinson's disease and multiple system atrophy, yet its functions remain obscure. When expressed in yeast, alpha-synuclein associated with the plasma membrane in a highly selective manner, before forming cytoplasmic inclusions through a concentration-dependent, nucleated process. Alpha-synuclein inhibited phospholipase D, induced lipid droplet accumulation, and affected vesicle trafficking. This readily manipulable system provides an opportunity to dissect the molecular pathways underlying normal alpha-synuclein biology and the pathogenic consequences of its misfolding.
Science of Aging Knowledge Environment. ISSN 1539-6150