Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Sci. Aging Knowl. Environ., 10 December 2003
Vol. 2003, Issue 49, p. or28

OTHER RESOURCES

Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

Tiago Fleming Outeiro, and Susan Lindquist

http://sageke.sciencemag.org/cgi/content/abstract/2003/49/or28

Abstract: Science 302, 1772-1775 (2003)

Alpha-synuclein is implicated in several neurodegenerative disorders, such as Parkinson's disease and multiple system atrophy, yet its functions remain obscure. When expressed in yeast, alpha-synuclein associated with the plasma membrane in a highly selective manner, before forming cytoplasmic inclusions through a concentration-dependent, nucleated process. Alpha-synuclein inhibited phospholipase D, induced lipid droplet accumulation, and affected vesicle trafficking. This readily manipulable system provides an opportunity to dissect the molecular pathways underlying normal alpha-synuclein biology and the pathogenic consequences of its misfolding.

Abstract/PDF

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150