Sci. Aging Knowl. Environ., 10 December 2003
Vol. 2003, Issue 49, p. or28


Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

Tiago Fleming Outeiro, and Susan Lindquist

Abstract: Science 302, 1772-1775 (2003)

Alpha-synuclein is implicated in several neurodegenerative disorders, such as Parkinson's disease and multiple system atrophy, yet its functions remain obscure. When expressed in yeast, alpha-synuclein associated with the plasma membrane in a highly selective manner, before forming cytoplasmic inclusions through a concentration-dependent, nucleated process. Alpha-synuclein inhibited phospholipase D, induced lipid droplet accumulation, and affected vesicle trafficking. This readily manipulable system provides an opportunity to dissect the molecular pathways underlying normal alpha-synuclein biology and the pathogenic consequences of its misfolding.


Science of Aging Knowledge Environment. ISSN 1539-6150