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Sci. Aging Knowl. Environ., 5 February 2003 PERSPECTIVESStructure-(Dys)function Relationships in Mitochondrial Electron Transport Chain Complex II?Bruce S. Kristal, and Boris F. Krasnikov The authors are with the Dementia Research Service of the Burke Medical Research Institute, White Plains, NY 10605, USA (B.S.K. and B.F.K.) and the Departments of Biochemistry and Neuroscience at Weill Medical College of Cornell University, New York, NY 10021, USA (B.S.K.). E-mail: bkristal{at}burke.org (B.S.K). http://sageke.sciencemag.org/cgi/content/full/sageke;2003/5/pe3Key Words: succinate dehydrogenase • mitochondria • electron transport • free radical theory of aging • reactive oxygen species
Abstract: It has been postulated that mitochondrially derived reactive oxygen species (ROS) play a major causative role in aging processes. The primary sources of these oxidants are believed to be complexes I and III of the electron transport chain, with little evidence supporting oxidant formation at complex II (succinate dehydrogenase). Mutation of a complex II protein has, however, been shown to cause increased oxidative stress and decreased life expectancy in the Caenorhabditis elegans mutant mev-1. A recent study by Yankovskaya and colleagues, in which the structure of Escherichia coli succinate dehydrogenase was determined, provides an explanation for these observations. Furthermore, these results suggest possible mechanisms by which electron leakage might occur at this site in the aged organism. Citation: B. S. Kristal, B. F. Krasnikov, Structure-(Dys)function Relationships in Mitochondrial Electron Transport Chain Complex II? Science's SAGE KE (5 February 2003), http://sageke.sciencemag.org/cgi/content/full/sageke;2003/5/pe3
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