Sci. Aging Knowl. Environ., 17 December 2003
Vol. 2003, Issue 50, p. ns8
[DOI: 10.1126/sageke.2003.50.ns8]


Power to the People

Experimental animals have taken center stage as researchers have connected insulin-related signaling to aging--and continuing studies should fill in the links. People with glitches in the mammalian versions of these pathways might also help researchers understand how the signals influence human aging

R. John Davenport

Abstract: Mutations that cripple a molecular relay system similar to the mammalian insulin and insulin-like growth factor 1 signaling pathways enhance longevity in worms and flies. The pathways appear to influence mammalian life span as well, but that idea is far from proven. Now, rare genetic perturbations in those signals are opening a window onto how the pathways influence human aging. And new studies on rodents with similar genetic snafus might help scientists ink in the connections.

Citation: R. J. Davenport, Power to the People. Sci. Aging Knowl. Environ. 2003 (50), ns8 (2003).

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Science of Aging Knowledge Environment. ISSN 1539-6150