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Sci. Aging Knowl. Environ., 17 December 2003
Vol. 2003, Issue 50, p. nw170
[DOI: 10.1126/sageke.2003.50.nw170]


Out, Out, Damned Zinc

Metal-grabbing antibiotic might hinder Alzheimer's disease

Mitch Leslie

Key Words: Alzheimer's Disease Assessment Scale • Mini-Mental State Examination • ApoE

Abstract: Michael Jordan returned from retirement to lead the Chicago Bulls to three straight NBA championships, and researchers hope that a chemical can pull off a similarly splashy comeback and challenge Alzheimer's disease. The first clinical trials of the drug, an antibiotic that was retired more than 30 years ago, suggest that it slows progression of the illness in the most severely affected patients. The work also supports the hypothesis that jumbled metal metabolism in the older brain promotes deterioration.

Citation: M. Leslie, Out, Out, Damned Zinc. Sci. Aging Knowl. Environ. 2003 (50), nw170 (2003).

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