Sci. Aging Knowl. Environ., 17 December 2003
Vol. 2003, Issue 50, p. nw172
[DOI: 10.1126/sageke.2003.50.nw172]


Catalase and Mouse

Enzyme-enhanced rodents scurry longer

Mitch Leslie

Key Words: Aconitase • cDNA • chick {beta}-actin promoter

Abstract: SCOTTSDALE, ARIZONA--Judging by their consumption of vitamin E supplements and antioxidant-packed foods such as blueberries, Americans have swallowed the idea that reactive oxygen species drive aging. Researchers aren't so sure, but new work gives the notion a boost. Mice that produce extra amounts of an enzyme that squelches oxidants survive longer, according to research presented here on 11 December at the Phoenix Conference on Longevity Health Sciences. The study is one of the few to address the role of antioxidant enzymes in mammalian aging by increasing rather than slashing their output.

Citation: M. Leslie, Catalase and Mouse. Sci. Aging Knowl. Environ. 2003 (50), nw172 (2003).

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