Sci. Aging Knowl. Environ., 26 February 2003
Vol. 2003, Issue 8, p. ns2
[DOI: 10.1126/sageke.2003.8.ns2]

NEWS SYNTHESIS

Get Wild

Single-gene mutations can dramatically alter aging of laboratory animals. Scientists are beginning to address whether those genes are relevant to aging in more natural settings

R. John Davenport

http://sageke.sciencemag.org/cgi/content/full/sageke;2003/8/ns2

Abstract: Numerous genetic alterations can profoundly extend the life-span of model organisms. But some researchers question whether the life-stretching effect is just a peculiarity of the lab and whether the same mutations influence survival in a natural environment. Scientists are beginning to test how long-lived animals fare in natural settings and whether life-extending mutations have a fighting chance in nature. The results suggest that the advantage depends on environment and other genes, and they could help guide the design of therapies for humans.

Citation: R. J. Davenport, Get Wild. Science's SAGE KE (26 February 2003), http://sageke.sciencemag.org/cgi/content/full/sageke;2003/8/ns2

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Science of Aging Knowledge Environment. ISSN 1539-6150