Sci. Aging Knowl. Environ., 26 February 2003
A growing number of researchers are finding that calorie restriction is not all it's cracked up to be. The regimen--long hailed as the only way to retard aging in a wide variety of animals--produces some distasteful side effects and doesn't always work
Abstract: The benefits of dietary restriction are well documented: Creatures that consume one-third fewer calories are leaner, livelier, and longer lived than their fully fed kin. But such drastic dieting also has a dark side. Restricted animals get chilled and pick up infections unusually easily, and they're less fertile than their more portly compatriots are. Furthermore, cutting calories doesn't enhance longevity in all animals, according to several studies. These observations have many researchers wondering what dietary restriction--or a drug that mimics its effects--might do for people who are hoping to live longer and healthier lives.
Citation: K. Hopkin, Dietary Drawbacks. Science's SAGE KE (26 February 2003), http://sageke.sciencemag.org/cgi/content/full/sageke;2003/8/ns4
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Science of Aging Knowledge Environment. ISSN 1539-6150