Sci. Aging Knowl. Environ., 5 March 2003
Vol. 2003, Issue 9, p. pe5
[DOI: 10.1126/sageke.2003.9.pe5]


Unearthing Loci That Influence Life Span

Marc Tatar

The author is in the Department of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912, USA. E-mail: marc_tatar{at};2003/9/pe5

Key Words: steroid hormones • ecdysone • Drosophila • gene expression

Abstract: It is known that certain hormones are involved in determining longevity (for example, insulin and insulin-like growth factor). Results presented in a paper published in this week's issue of Science allow us to add steroid hormones to this list. Anne Simon and colleagues show for the first time that a sterol hormone--ecdysone of the fly Drosophila melanogaster--regulates life span. In this Perspective, I discuss the implications of this result in the context of gene regulation and mechanisms of aging.

Citation: M. Tatar, Unearthing Loci That Influence Life Span. Sci. SAGE KE 2003, pe5 (5 March 2003);2003/9/pe5

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Science of Aging Knowledge Environment. ISSN 1539-6150