Sci. Aging Knowl. Environ., 7 January 2004
Vol. 2004, Issue 1, p. nf5
[DOI: 10.1126/sageke.2004.1.nf5]

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UnSIRtainty Principle

Conflicting results underscore questions about how calorie restriction activates yeast longevity enzyme

R. John Davenport

http://sageke.sciencemag.org/cgi/content/full/2004/1/nf5

Abstract: Stemming sugar intake sparks a yeast longevity protein, and two new studies offer differing views of the mechanism. The data clash on whether cutting calories reduces amounts of a particular enzyme blocker. Resolving this issue could help clarify how metabolic changes induced by this diet lengthen life in yeast--and whether related changes might do the same in mammals.

Citation: R. J. Davenport, UnSIRtainty Principle. Sci. Aging Knowl. Environ. 2004 (1), nf5 (2004).

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