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Sci. Aging Knowl. Environ., 7 January 2004
Vol. 2004, Issue 1, p. pe1
[DOI: 10.1126/sageke.2004.1.pe1]


There's a Problem in the Furnace

John Tower

The author is in the Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA. E-mail: jtower{at}

Key Words: superoxide dismutase • oxidative damage • reactive oxygen species

Abstract: A long-sought-after mutation in the manganese superoxide dismutase gene MnSOD has been isolated in Drosophila melanogaster. The MnSOD null mutation is recessive lethal, with death occurring just after eclosion. In this Perspective, I discuss these results and related work in mice within the context of the oxidative damage theory of aging.

Citation: J. Tower, There's a Problem in the Furnace. Sci. Aging Knowl. Environ. 2004 (1), pe1 (2004).

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Science of Aging Knowledge Environment. ISSN 1539-6150