Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Aging Knowl. Environ., 24 March 2004
Vol. 2004, Issue 12, p. pe13
[DOI: 10.1126/sageke.2004.12.pe13]


How Good Are Quantitative Complementation Tests?

Philip M. Service

The author is in the Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA. E-mail: Philip.Service{at}

Key Words: quantitative complementation test • life-span gene • Drosophila • quantitative genetics • QTL mapping

Abstract: Several recent studies have used quantitative complementation tests to identify relatively short chromosome regions that contain genes that influence life span and to screen for candidate life-span genes in flies. The methodology and logic of quantitative complementation tests are described. Arguments are presented that suggest that these tests may be misleading because there is a substantial, but unknown, likelihood of false positive results. The arguments are supported by the published results of quantitative complementation tests.

Citation: P. M. Service, How Good Are Quantitative Complementation Tests? Sci. Aging Knowl. Environ. 2004 (12), pe13 (2004).

Read the Full Text

A Noncomplementation Screen for Quantitative Trait Alleles in Saccharomyces cerevisiae.
H. S. Kim, J. Huh, L. Riles, A. Reyes, and J. C. Fay (2017)
g3 2, 753-760
   Abstract »    Full Text »    PDF »
Fine-Mapping and Selective Sweep Analysis of QTL for Cold Tolerance in Drosophila melanogaster.
R. Wilches, S. Voigt, P. Duchen, S. Laurent, and W. Stephan (2017)
g3 4, 1635-1645
   Abstract »    Full Text »    PDF »
Combining Genome-Wide Methods to Investigate the Genetic Complexity of Courtship Song Variation in Drosophila melanogaster.
T. L. Turner, P. M. Miller, and V. A. Cochrane (2013)
Mol. Biol. Evol. 30, 2113-2120
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150