Sci. Aging Knowl. Environ., 24 March 2004
Vol. 2004, Issue 12, p. pe13
[DOI: 10.1126/sageke.2004.12.pe13]

PERSPECTIVES

How Good Are Quantitative Complementation Tests?

Philip M. Service

The author is in the Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA. E-mail: Philip.Service{at}nau.edu

http://sageke.sciencemag.org/cgi/content/full/2004/12/pe13

Key Words: quantitative complementation test • life-span gene • Drosophila • quantitative genetics • QTL mapping

Abstract: Several recent studies have used quantitative complementation tests to identify relatively short chromosome regions that contain genes that influence life span and to screen for candidate life-span genes in flies. The methodology and logic of quantitative complementation tests are described. Arguments are presented that suggest that these tests may be misleading because there is a substantial, but unknown, likelihood of false positive results. The arguments are supported by the published results of quantitative complementation tests.

Citation: P. M. Service, How Good Are Quantitative Complementation Tests? Sci. Aging Knowl. Environ. 2004 (12), pe13 (2004).

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