Sci. Aging Knowl. Environ., 7 April 2004
Vol. 2004, Issue 14, p. nf36
[DOI: 10.1126/sageke.2004.14.nf36]


More Without TOR

Inhibiting nutrient sensor extends life span in fruit flies

Mary Beckman

Abstract: Scarfing pizzas wouldn't shorten a person's life if the body didn't notice the extra intake. Similarly, flies can eat rich food and not die early if a nutrient-sensing gadget is turned down, according to a new study. Quelling a protein that detects an abundance of food delays fly death, the work shows. The result suggests a potential mechanistic connection between decreased insulin-like signaling and calorie restriction, two manipulations that increase life span.

Citation: M. Beckman, More Without TOR. Sci. Aging Knowl. Environ. 2004 (14), nf36 (2004).

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