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Sci. Aging Knowl. Environ., 7 April 2004 OTHER RESOURCESEndothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem CellsQin Shen, Susan Goderie, Li Jin, Nithin Karanth, Yu Sun, Natalie Abramova, Peter Vincent, Kevin Pumiglia, and Sally Temple http://sageke.sciencemag.org/cgi/content/abstract/2004/14/or7Abstract: Science 2 April 2004 (10.1126/science.1095505) (Science Express Reports) Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship. We show that endothelial cells, but not vascular smooth muscle cells, release soluble factors that stimulate self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial co-culture stimulates neuroepithelial cell contact, activating Notch and Hes1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche.
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