Sci. Aging Knowl. Environ., 14 April 2004
Vol. 2004, Issue 15, p. pe15
[DOI: 10.1126/sageke.2004.15.pe15]


A New Way to Lose Your Nerve

Allan I. Basbaum

Allan I. Basbaum is in the Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA. E-mail: aib{at}

Key Words: peripheral nervous system • postherpetic neuralgia • shingles • pain

Abstract: Perpiheral nerve damage results in loss of sensation in the affected region of the body. Oaklander and Brown now report that, in the rat, transection of a peripheral nerve in only one side of the body also results in profound loss of the innervation of the same region on the opposite side of the body. Peripheral nerve damage may also produce persistent (neuropathic) pain conditions that are presumed to arise from maladaptive reorganization of the central nervous system. Thus, the possibility that comparable bilateral changes occur in patients and that such changes contribute to neuropathic pain conditions must be considered.

Citation: A. I. Basbaum, A New Way to Lose Your Nerve. Sci. Aging Knowl. Environ. 2004 (15), pe15 (2004).

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