Sci. Aging Knowl. Environ., 21 April 2004
Vol. 2004, Issue 16, p. nf43
[DOI: 10.1126/sageke.2004.16.nf43]


Lethal Leak

Protein that shortens mouse life span opens holes in mitochondria

R. John Davenport

Abstract: Perforating mitochondria might accelerate aging, according to a new study. A protein called p66shc that speeds the demise of mice breaches these organelles, a key event in cell death. The work reveals new information about p66shc's workings, but researchers caution that they don't yet know whether the protein influences life span through this route.

Citation: R. J. Davenport, Lethal Leak. Sci. Aging Knowl. Environ. 2004 (16), nf43 (2004).

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