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Sci. Aging Knowl. Environ., 28 April 2004 NEWS SYNTHESISMany Roads to RuinOrgans such as the heart and brain don't work the same way, nor do they fall apart the same way over time. Now the reasons for these differences are becoming clearMitch Leslie http://sageke.sciencemag.org/cgi/content/full/2004/17/ns2Abstract: As researchers begin to understand the molecular faults that weaken tissues and organs over time, they are learning that some types of trouble undermine specific tissues and others affect multiple tissues. In certain tissues, for example, mature cells kill themselves in droves. In muscles, stem cells that fix injuries stop dividing. In the bones and arteries, stem cells specialize inappropriately. Putting stem cells back to work might allow scientists to repair damage. By prodding them in the bone marrow, for example, researchers might coax the damaged heart to repair itself. Citation: M. Leslie, Many Roads to Ruin. Sci. Aging Knowl. Environ. 2004 (17), ns2 (2004).
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