Sci. Aging Knowl. Environ., 5 May 2004
Vol. 2004, Issue 18, p. nf46
[DOI: 10.1126/sageke.2004.18.nf46]

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Slacking Off

DNA-break repair pathway poops out in older cells

Esther Landhuis

http://sageke.sciencemag.org/cgi/content/full/2004/18/nf46

Abstract: Like students whose motivation level wanes as summer nears, a molecular crew that mends fractured DNA gets lazy toward the end of an animal's life, according to new work. The findings spotlight a pathway whose breakdown could explain how elderly genomes become riddled with errors, which boosts cancer risk.

Citation: E. Landhuis, Slacking Off. Sci. Aging Knowl. Environ. 2004 (18), nf46 (2004).

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