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Sci. Aging Knowl. Environ., 5 May 2004
Vol. 2004, Issue 18, p. pe18
[DOI: 10.1126/sageke.2004.18.pe18]

PERSPECTIVES

Come One, Come All

Siu Sylvia Lee

The author is in the Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA. E-mail: SSL29{at}cornell.edu

http://sageke.sciencemag.org/cgi/content/full/2004/18/pe18

Key Words: C. elegansdaf-2 • gene expression • microarrays

Abstract: Aging is a complex process that involves the gradual functional decline of many different tissues and cells. Gene expression microarray analysis provides a comprehensive view of the gene expression signature associated with age and is particularly valuable for understanding the molecular mechanisms that contribute to the aging process. However, because of the stochastic nature of the aging process, animals of the same chronological age often manifest great physiological differences. Therefore, profiling the gene expression pattern of a large population of aging animals risks either exaggerating or masking the changes in gene expression that correspond to physiological aging. In a recent paper, Golden and Melov surveyed the gene expression profiles of individual aging Caenorhabditis elegans, hoping to circumvent the problem of variability among worms of the same chronological age. This initial analysis of age-dependent gene expression in individual aging worms is an important step toward deciphering the molecular basis of physiological aging.

Citation: S. S. Lee, Come One, Come All. Sci. Aging Knowl. Environ. 2004 (18), pe18 (2004).

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Science of Aging Knowledge Environment. ISSN 1539-6150