Sci. Aging Knowl. Environ., 12 May 2004
Vol. 2004, Issue 19, p. nf48
[DOI: 10.1126/sageke.2004.19.nf48]

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Calorie Restriction Un-SIR-tainty

Yeast don't need SIR2 to starve their way to long life

R. John Davenport

http://sageke.sciencemag.org/cgi/content/full/2004/19/nf48

Abstract: HERSONISSOS, CRETE, GREECE--Like connections between characters in a Greek tragedy, the relation between calorie restriction (CR) and a longevity gene might not be what it has seemed. New work presented here 1 May at the 2nd International Conference on Functional Genomics of Ageing suggests that curbing food intake doesn't require the SIR2 gene to extend yeast longevity. The result challenges the prevailing model for how CR works, although some researchers don't rule out a contribution from SIR2.

Citation: R. J. Davenport, Calorie Restriction Un-SIR-tainty. Sci. Aging Knowl. Environ. 2004 (19), nf48 (2004).

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