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Sci. Aging Knowl. Environ., 12 May 2004
Vol. 2004, Issue 19, p. pe19
[DOI: 10.1126/sageke.2004.19.pe19]


Vital Connections

Scott D. Pletcher

The author is in the Department of Molecular and Human Genetics and at the Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA. E-mail: pletcher{at}

Key Words: scale-free network • protein interaction • pleiotropy • Saccharomyces cerevisiae

Abstract: Scientists are currently exploring the structure and behavior of complex biological systems, which consist of networks of interacting entities. A recent paper in Proceedings of the Royal Society of London Series B Biological Sciences describes the distinctive characteristics of aging-related proteins in the yeast protein-protein interaction network. In this Perspective, I discuss the implications of these findings for longevity research.

Citation: S. D. Pletcher, Vital Connections. Sci. Aging Knowl. Environ. 2004 (19), pe19 (2004).

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Science of Aging Knowledge Environment. ISSN 1539-6150