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Sci. Aging Knowl. Environ., 2 June 2004 PERSPECTIVESBreaking in a New Function for Casein Kinase 2Julio C. Morales, and Phillip B. Carpenter The authors are in the Department of Biochemistry and Molecular Biology at the University of Texas-Houston Medical School, Houston, TX 77225, USA. E-mail: Phillip.B.Carpenter{at}uth.tmc.edu (P.B.C.) http://sageke.sciencemag.org/cgi/content/full/2004/22/pe24Key Words: DNA damage • DNA repair • single-stranded break repair • XRCC1
Abstract: DNA damage response mechanisms help ensure the fidelity of chromosomal transmission, and the failure of such mechanisms might lead to premature aging and cancer. A new report has established that casein kinase 2 (CK2), a protein that functions in diverse cellular processes, controls the activity of the DNA repair protein XRCC1. These results indicate that CK2 is a key participant in the cellular response to DNA damage. Citation: J. C. Morales, P. B. Carpenter, Breaking in a New Function for Casein Kinase 2. Sci. Aging Knowl. Environ. 2004 (22), pe24 (2004).
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