Sci. Aging Knowl. Environ., 9 June 2004
By squelching a fat-storage pathway, protein might connect diet with extended life
Abstract: Like a cutthroat politician, a potential longevity protein acts by derailing another molecule with opposing aims. According to new work, SIRT1 seems to spur fat breakdown in food-deprived animals by thwarting the actions of PPAR, a protein that activates fat-storage genes. Fat loss prolongs life in mice, so the findings suggest a possible molecular pathway that links diet to mammalian longevity.
Citation: E. Landhuis, Counterattack. Sci. Aging Knowl. Environ. 2004 (23), nf57 (2004).
Science of Aging Knowledge Environment. ISSN 1539-6150