Sci. Aging Knowl. Environ., 9 June 2004
Vol. 2004, Issue 23, p. nf57
[DOI: 10.1126/sageke.2004.23.nf57]



By squelching a fat-storage pathway, protein might connect diet with extended life

Esther Landhuis

Abstract: Like a cutthroat politician, a potential longevity protein acts by derailing another molecule with opposing aims. According to new work, SIRT1 seems to spur fat breakdown in food-deprived animals by thwarting the actions of PPAR{gamma}, a protein that activates fat-storage genes. Fat loss prolongs life in mice, so the findings suggest a possible molecular pathway that links diet to mammalian longevity.

Citation: E. Landhuis, Counterattack. Sci. Aging Knowl. Environ. 2004 (23), nf57 (2004).

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