Sci. Aging Knowl. Environ., 9 June 2004
Vol. 2004, Issue 23, p. pe25
[DOI: 10.1126/sageke.2004.23.pe25]

PERSPECTIVES

Inside Insulin Signaling, Communication Is Key to Long Life

Adam Antebi

Adam Antebi is in the Max-Planck-Institut für Molekulare Genetik, Ihnestrasse 73, D-14195 Berlin, Germany. E-mail: antebi{at}molgen.mpg.de

http://sageke.sciencemag.org/cgi/content/full/2004/23/pe25

Key Words: insulin/IGF signaling • fat body • Drosophila • oxidative stress

Abstract: In a recent Nature paper (1), Tatar and colleagues show that inhibition of insulin/insulin-like growth factor (IGF) signaling specifically in the adipose tissue of Drosophila melanogaster retards organismal aging, increases resistance to oxidative stress, augments lipid deposition, and restricts insulin signaling in peripheral tissues by a cell-non-autonomous mechanism. Consistent with recent work in the worm, these results suggest that insulin/IGF signaling itself may mediate communication among various tissues to influence organismal longevity.

Citation: A. Antebi, Inside Insulin Signaling, Communication Is Key to Long Life. Sci. Aging Knowl. Environ. 2004 (23), pe25 (2004).

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