Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Aging Knowl. Environ., 9 June 2004
Vol. 2004, Issue 23, p. pe26
[DOI: 10.1126/sageke.2004.23.pe26]

PERSPECTIVES

Neurodegeneration in Normal Brain Aging and Disease

Dietmar Rudolf Thal, Kelly Del Tredici, and Heiko Braak

Dietmar R. Thal is in the Department of Neuropathology at the University of Bonn Medical Center, Sigmund Freud Strasse 25, D-53105 Bonn, Germany. Kelly Del Tredici and Heiko Braak are at the Institute for Clinical Neuroanatomy at Johann Wolfgang Goethe University, D-60590 Frankfurt am Main, Germany. E-mail: Dietmar.Thal{at}uni-bonn.de (D.R.T.)

http://sageke.sciencemag.org/cgi/content/full/2004/23/pe26

Key Words: Alzheimer's disease • Parkinson's disease • cerebrovascular disease • preclinical stages

Abstract: Normal "healthy" aging is defined as aging without disease. Many aged people do not exhibit symptoms of disease and lead normal lives, but nonetheless display pathological changes that are characteristic of Alzheimer's disease (AD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), and/or cerebrovascular disease (CVD). These changes are restricted to distinct brain regions and might represent preclinical stages of these disorders. This Perspective discusses arguments in favor of and against the hypothesis that pathological changes related to AD, PD, DLB, and CVD in the brains of nondemented elderly people represent early stages of these diseases rather than healthy aging. We conclude that early pathological disease-related changes do indeed constitute the beginning of AD, PD, DLB, and CVD rather than normal concomitants of aging, even in the absence of any clinical symptoms. Aging is, therefore, a major risk factor for these diseases but does not necessarily lead to age-related diseases.

Citation: D. R. Thal, K. Del Tredici, H. Braak, Neurodegeneration in Normal Brain Aging and Disease. Sci. Aging Knowl. Environ. 2004 (23), pe26 (2004).

Read the Full Text




THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
"New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS).
P. T. Nelson, J. Q. Trojanowski, E. L. Abner, O. M. Al-Janabi, G. A. Jicha, F. A. Schmitt, C. D. Smith, D. W. Fardo, W.-X. Wang, R. J. Kryscio, et al. (2016)
J Neuropathol Exp Neurol 75, 482-498
   Abstract »    Full Text »    PDF »
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature.
P. T. Nelson, I. Alafuzoff, E. H. Bigio, C. Bouras, H. Braak, N. J. Cairns, R. J. Castellani, B. J. Crain, P. Davies, K. D. Tredici, et al. (2012)
J Neuropathol Exp Neurol 71, 362-381
   Abstract »    Full Text »    PDF »
Invited Commentary.
T. Y. Liu-Ambrose (2011)
Physical Therapy 91, 1208-1210
   Full Text »    PDF »
Autophagy for the avoidance of neurodegeneration.
F. Madeo, T. Eisenberg, and G. Kroemer (2009)
Genes & Dev. 23, 2253-2259
   Abstract »    Full Text »    PDF »
Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship.
P. T. Nelson, H. Braak, and W. R. Markesbery (2009)
J Neuropathol Exp Neurol 68, 1-14
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science of Aging Knowledge Environment. ISSN 1539-6150