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Sci. Aging Knowl. Environ., 16 June 2004 HOT TOPIC ORIENTATIONSOn TrialImplicit in any basic research investigation of aging is the hope that its findings will apply to people. But testing theories from the lab in human populations presents unique challengesR. John Davenport http://sageke.sciencemag.org/cgi/content/full/2004/24/oa1Abstract: As researchers uncover basic mechanisms that underlie aging, they hope that lessons learned from mice, worms, flies, and other lab denizens will apply to people. Making that leap requires a new set of scientific approaches, from observational studies to the most rigorous of tests, the double-blind, randomized, placebo-controlled clinical trial. Navigating this unique scientific terrain presents new obstacles for basic-science researchers but can provide the ultimate payoff. Citation: R. J. Davenport, On Trial. Sci. Aging Knowl. Environ. 2004 (24), oa1 (2004).
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