Sci. Aging Knowl. Environ., 16 June 2004
Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body
Maria E. Giannakou, Martin Goss, Martin A. Jünger, Ernst Hafen, Sally J. Leevers, and Linda Partridgehttp://sageke.sciencemag.org/cgi/content/abstract/2004/24/or13
Abstract: Science 10 June 2004 (10.1126/science.1098219) (Science Express Reports)
Reduced activity of the insulin/IGF-like signaling (IIS) pathway increases life span in diverse organisms. We investigated the timing of the effect of reduced IIS on life span and the role of a potential target tissue, the fat body. We overexpressed dFOXO, a key downstream effector of IIS, in the fat body of adults, which led to increased life span and reduced fecundity of females, but had no effect on male life span. The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in regulating aging, and reduction of IIS in the adult is sufficient to mediate the effects on life span and fecundity.
Science of Aging Knowledge Environment. ISSN 1539-6150