Sci. Aging Knowl. Environ., 23 June 2004
Vol. 2004, Issue 25, p. nf60
[DOI: 10.1126/sageke.2004.25.nf60]


Low-Cal Connections

Calorie restriction might harness life-span extension protein to stop cell suicide

Mary Beckman

Abstract: Less food can mean more protein--a specific protein, that is. The life-prolonging regime of calorie restriction (CR) boosts quantities of SIRT1, a potential mammalian longevity molecule, new research shows. The protein protects cells by blocking stress-induced suicide, suggesting that CR lengthens animals' lives at least in part by preserving irreplaceable cells. The results hint that several seemingly disparate life-extending methods overlap.

Citation: M. Beckman, Low-Cal Connections. Sci. Aging Knowl. Environ. 2004 (25), nf60 (2004).

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