Sci. Aging Knowl. Environ., 7 July 2004
A Twist in an Early End
Snafus in telomere unwinding foster a premature aging syndrome
R. John Davenporthttp://sageke.sciencemag.org/cgi/content/full/2004/27/nf63
Abstract: Patients with Werner syndrome show signs of rapid aging, perhaps because their chromosomes come to an abrupt end, two new studies suggest. Mice that lack the Werner syndrome protein (WRN) deteriorate quickly only if they also harbor short telomeres, protective caps that guard the ends of chromosomes. Furthermore, WRN flocks to telomeres and unravels structures there. The work solidifies the idea that telomere malfunction contributes to the disease.
Citation: R. J. Davenport, A Twist in an Early End. Sci. Aging Knowl. Environ. 2004 (27), nf63 (2004).
Science of Aging Knowledge Environment. ISSN 1539-6150