Sci. Aging Knowl. Environ., 7 July 2004
Vol. 2004, Issue 27, p. nf63
[DOI: 10.1126/sageke.2004.27.nf63]


A Twist in an Early End

Snafus in telomere unwinding foster a premature aging syndrome

R. John Davenport

Abstract: Patients with Werner syndrome show signs of rapid aging, perhaps because their chromosomes come to an abrupt end, two new studies suggest. Mice that lack the Werner syndrome protein (WRN) deteriorate quickly only if they also harbor short telomeres, protective caps that guard the ends of chromosomes. Furthermore, WRN flocks to telomeres and unravels structures there. The work solidifies the idea that telomere malfunction contributes to the disease.

Citation: R. J. Davenport, A Twist in an Early End. Sci. Aging Knowl. Environ. 2004 (27), nf63 (2004).

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