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Sci. Aging Knowl. Environ., 28 July 2004
Vol. 2004, Issue 30, p. dn1
[DOI: 10.1126/sageke.2004.30.dn1]

NEURODEGENERATIVE DISEASE CASE STUDIES

Progressive Supranuclear Palsy

Michael Pourfar, and Jean-Paul Vonsattel

Michael Pourfar is at the Center for Parkinson's Disease and Other Movement Disorders, Columbia University Medical Center, New York, NY 10032, USA. Jean-Paul Vonsattel is a professor of Pathology and director of the New York Brain Bank, Taub Institute of Pathology, Columbia University Medical Center, New York, NY 10032, USA. E-mail: M.Pourfar{at}neuro.columbia.edu (M.P.)

http://sageke.sciencemag.org/cgi/content/full/2004/30/dn1

Key Words: tauopathy

Abstract: In this case study, we describe the symptoms, neurological examination, clinical course, and neuropathology of a patient with progressive supranuclear palsy (PSP). PSP is a relatively uncommon neurodegenerative disorder with many features similar to those of Parkinson's disease. It is characterized by slow motor function, ocular movement abnormalities, dystonia, and cognitive disabilities. PSP is largely a sporadic disorder caused by accumulation of the protein tau in diverse regions of the central nervous system. It is thus classified as one of several tauopathies. The exact cause of the disease remains unknown, and treatment is often limited. The following case provides a framework to explore the manifestations of PSP, as well as the progress made in understanding the nature of this challenging disorder.

Citation: M. Pourfar, J.-P. Vonsattel, Progressive Supranuclear Palsy. Sci. Aging Knowl. Environ. 2004 (30), dn1 (2004).

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Science of Aging Knowledge Environment. ISSN 1539-6150