Sci. Aging Knowl. Environ., 18 August 2004
NAD to the Rescue
Antonio Bedalov, and Julian A. Simonhttp://sageke.sciencemag.org/cgi/content/abstract/2004/33/or14
Abstract: Science 305, 954-955 (2004).
Identified 15 years ago, the Wlds mouse carries a spontaneous mutation that encodes a fusion protein with neuroprotective properties. In a Perspective, Simon discusses new work (Araki et al.) that identifies the Nmnat1 fragment of the fusion protein as mediating neuroprotection by boosting NAD biosynthesis and increasing the activity of the NAD-dependent deacetylase, SIRT1, a regulator of transcription.
Science of Aging Knowledge Environment. ISSN 1539-6150