Sci. Aging Knowl. Environ., 18 August 2004
Vol. 2004, Issue 33, p. or14

OTHER RESOURCES

NAD to the Rescue

Antonio Bedalov, and Julian A. Simon

http://sageke.sciencemag.org/cgi/content/abstract/2004/33/or14

Abstract: Science 305, 954-955 (2004).

Identified 15 years ago, the Wlds mouse carries a spontaneous mutation that encodes a fusion protein with neuroprotective properties. In a Perspective, Simon discusses new work (Araki et al.) that identifies the Nmnat1 fragment of the fusion protein as mediating neuroprotection by boosting NAD biosynthesis and increasing the activity of the NAD-dependent deacetylase, SIRT1, a regulator of transcription.

[Abstract/Full Text]








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