Sci. Aging Knowl. Environ., 18 August 2004
Vol. 2004, Issue 33, p. or14


NAD to the Rescue

Antonio Bedalov, and Julian A. Simon

Abstract: Science 305, 954-955 (2004).

Identified 15 years ago, the Wlds mouse carries a spontaneous mutation that encodes a fusion protein with neuroprotective properties. In a Perspective, Simon discusses new work (Araki et al.) that identifies the Nmnat1 fragment of the fusion protein as mediating neuroprotection by boosting NAD biosynthesis and increasing the activity of the NAD-dependent deacetylase, SIRT1, a regulator of transcription.

[Abstract/Full Text]

Science of Aging Knowledge Environment. ISSN 1539-6150