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Sci. Aging Knowl. Environ., 8 September 2004
Vol. 2004, Issue 36, p. pe34
[DOI: 10.1126/sageke.2004.36.pe34]

PERSPECTIVES

TOR Pathway: Linking Nutrient Sensing to Life Span

Pankaj Kapahi, and Brian Zid

Pankaj Kapahi is at the Buck Institute for Age Research, Novato, CA 94945, USA. Brian Zid is in the Division of Biology at the California Institute of Technology, Pasadena, CA 91125, USA. E-mail: Pkapahi{at}buckinstitute.org (P.K.)

http://sageke.sciencemag.org/cgi/content/full/2004/36/pe34

Key Words: dietary restriction • amino acid transport • nutrition • autophagy • protein synthesis • translation

Abstract: Recent studies point to an emerging role for the TOR (target of rapamycin) pathway in the regulation of life span. In this Perspective, we discuss the possibility that this pathway is an important modulator of nutrient-dependent changes in life span. Additionally, we discuss the interactions between the TOR and insulin-like signaling pathways as well as the key downstream processes that TOR regulates.

Citation: P. Kapahi, B. Zid, TOR Pathway: Linking Nutrient Sensing to Life Span. Sci. Aging Knowl. Environ. 2004 (36), pe34 (2004).

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Science 327, 1223-1228
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