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Sci. Aging Knowl. Environ., 29 September 2004
Vol. 2004, Issue 39, p. nf89
[DOI: 10.1126/sageke.2004.39.nf89]

NEWS FOCUS

Knife Jugglers

Painkillers shift Alzheimer's protein slicer

R. John Davenport

http://sageke.sciencemag.org/cgi/content/full/2004/39/nf89

Abstract: A small slip at the cutting board can mean the difference between beautifully diced vegetables and a severed finger. An even more subtle miss might explain how one class of painkillers reduces the risk of Alzheimer's disease (AD). According to new work, the drugs nudge a cellular butcher, prodding it to dice a protein into a harmless form rather than one that clumps in the brains of AD patients. The study reveals how the painkillers alter the protein chopper and might provide a new method for identifying potential AD drugs.

Citation: R. J. Davenport, Knife Jugglers. Sci. Aging Knowl. Environ. 2004 (39), nf89 (2004).

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