Sci. Aging Knowl. Environ., 29 September 2004
Painkillers shift Alzheimer's protein slicer
R. John Davenporthttp://sageke.sciencemag.org/cgi/content/full/2004/39/nf89
Abstract: A small slip at the cutting board can mean the difference between beautifully diced vegetables and a severed finger. An even more subtle miss might explain how one class of painkillers reduces the risk of Alzheimer's disease (AD). According to new work, the drugs nudge a cellular butcher, prodding it to dice a protein into a harmless form rather than one that clumps in the brains of AD patients. The study reveals how the painkillers alter the protein chopper and might provide a new method for identifying potential AD drugs.
Citation: R. J. Davenport, Knife Jugglers. Sci. Aging Knowl. Environ. 2004 (39), nf89 (2004).
Science of Aging Knowledge Environment. ISSN 1539-6150