Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Aging Knowl. Environ., 29 September 2004
Vol. 2004, Issue 39, p. pe36
[DOI: 10.1126/sageke.2004.39.pe36]

PERSPECTIVES

Ras: The Other Pro-Aging Pathway

Valter D. Longo

The author is in the Andrus Gerontology Center and Department of Biological Sciences at the University of Southern California, Los Angeles, CA 90089, USA. E-mail: vlongo{at}usc.edu

http://sageke.sciencemag.org/cgi/content/full/2004/39/pe36

Key Words: Ras • Akt • insulin/insulin-like growth factor-1 • chronological aging • yeast

Abstract: Studies in worms, flies, and mice point to the insulin/insulin-like growth factor-1 (IGF-1)/phosphatidylinositol 3-kinase/Akt-like pathway as a central regulator of longevity. A similar pathway, which includes Sch9, a functional mammalian Akt/protein kinase B homolog, regulates longevity in yeast. Chronological aging in yeast is also regulated by a second pathway that includes Ras, adenylate cyclase, protein kinase A, the transcription factors Msn2 and Msn4, and Sod2. Although Ras proteins have not been implicated in longevity regulation in worms or flies, the major role of Ras in mammalian IGF-1 signaling raises the possibility that homologs of yeast Ras2 might accelerate aging in mammals. Here I review the data from experiments at both the organismal and cellular levels that support a role for Ras in the regulation of stress resistance and life span in eukaryotes.

Citation: V. D. Longo, Ras: The Other Pro-Aging Pathway. Sci. Aging Knowl. Environ. 2004 (39), pe36 (2004).

Read the Full Text




THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Actin-Induced Hyperactivation of the Ras Signaling Pathway Leads to Apoptosis in Saccharomyces cerevisiae.
C. W. Gourlay and K. R. Ayscough (2006)
Mol. Cell. Biol. 26, 6487-6501
   Abstract »    Full Text »    PDF »
Extension of chronological life span in yeast by decreased TOR pathway signaling.
R. W. Powers III, M. Kaeberlein, S. D. Caldwell, B. K. Kennedy, and S. Fields (2006)
Genes & Dev. 20, 174-184
   Abstract »    Full Text »    PDF »
Making Young Tumors Old: A New Weapon Against Cancer?.
J. Sage (2005)
Sci. Aging Knowl. Environ. 2005, pe25
   Abstract »    Full Text »



To Advertise     Find Products


Science of Aging Knowledge Environment. ISSN 1539-6150