Sci. Aging Knowl. Environ., 28 January 2004
Vol. 2004, Issue 4, p. nf12
[DOI: 10.1126/sageke.2004.4.nf12]


Plaque Attack

Mice without ApoE and related protein unexpectedly accumulate {beta}-amyloid deposits

R. John Davenport

Abstract: A person can toss her wadded-up burger wrapper into either the gutter or a trash bin. New work establishes that ApoE, a protein connected to Alzheimer's disease (AD), makes a similar choice. Mouse studies have suggested that ApoE encourages formation of the {beta}-amyloid plaques that gum up patients' brains. But scientists now suggest that ApoE helps clear {beta} amyloid from the brain before it forms plaques. The results warn that targeting ApoE as an AD treatment will require balancing its positive and negative influences.

Citation: R. J. Davenport, Plaque Attack. Sci. Aging Knowl. Environ. 2004 (4), nf12 (2004).

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