Sci. Aging Knowl. Environ., 28 January 2004
Mice without ApoE and related protein unexpectedly accumulate -amyloid deposits
R. John Davenporthttp://sageke.sciencemag.org/cgi/content/full/2004/4/nf12
Abstract: A person can toss her wadded-up burger wrapper into either the gutter or a trash bin. New work establishes that ApoE, a protein connected to Alzheimer's disease (AD), makes a similar choice. Mouse studies have suggested that ApoE encourages formation of the -amyloid plaques that gum up patients' brains. But scientists now suggest that ApoE helps clear amyloid from the brain before it forms plaques. The results warn that targeting ApoE as an AD treatment will require balancing its positive and negative influences.
Citation: R. J. Davenport, Plaque Attack. Sci. Aging Knowl. Environ. 2004 (4), nf12 (2004).
Science of Aging Knowledge Environment. ISSN 1539-6150