Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. Aging Knowl. Environ., 28 January 2004
Vol. 2004, Issue 4, p. pe4
[DOI: 10.1126/sageke.2004.4.pe4]


Frailty--The Search For Underlying Causes

Jeremy Walston

The author is at the Center on Aging and Health in the Division of Geriatric Medicine and Gerontology at the Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. E-mail:

Key Words: frailty • weakness • fatigue • inflammation • cytokine IL-6

Abstract: Research into the biological basis of frailty has been difficult to accomplish because of a lack of standardized definitions, disease and disability confounders, and complex multifactorial etiology. Multiple physiological systems are likely to be involved, including the skeletal muscle, endocrine, and immune/inflammation systems. Physiological characterization of frail older adults might provide etiologic clues. Translational research programs that connect mechanisms related to aging, such as oxidative damage and telomere shortening, to clinical aging-related syndromes will be necessary to further this critical area of geriatric research.

Citation: J. Walston, Frailty--The Search For Underlying Causes. Sci. Aging Knowl. Environ. 2004 (4), pe4 (2004).

Read the Full Text

Indications, Labeling, and Outcomes Assessment for Drugs Aimed at Improving Functional Status in Older Persons: A Conversation Between Aging Researchers and FDA Regulators.
Working Group on Functional Outcome Measures for C (2009)
J Gerontol A Biol Sci Med Sci 64A, 487-491
   Full Text »    PDF »
Statin Use and Incident Frailty in Women Aged 65 Years or Older: Prospective Findings From the Women's Health Initiative Observational Study.
A. Z. LaCroix, S. L. Gray, A. Aragaki, B. B. Cochrane, A. B. Newman, C. L. Kooperberg, H. Black, J. D. Curb, P. Greenland, and N. F. Woods (2008)
J Gerontol A Biol Sci Med Sci 63, 369-375
   Abstract »    Full Text »    PDF »
HIV-1 Infection Is Associated With an Earlier Occurrence of a Phenotype Related to Frailty.
L. Desquilbet, L. P. Jacobson, L. P. Fried, J. P. Phair, B. D. Jamieson, M. Holloway, J. B. Margolick, and for the Multicenter AIDS Cohort Study (2007)
J Gerontol A Biol Sci Med Sci 62, 1279-1286
   Abstract »    Full Text »    PDF »
From Bedside to Bench: Research Agenda for Frailty.
L. P. Fried, E. C. Hadley, J. D. Walston, A. B. Newman, J. M. Guralnik, S. Studenski, T. B. Harris, W. B. Ershler, and L. Ferrucci (2005)
Sci. Aging Knowl. Environ. 2005, pe24
   Abstract »    Full Text »

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150