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Sci. Aging Knowl. Environ., 28 January 2004
Vol. 2004, Issue 4, p. pe4
[DOI: 10.1126/sageke.2004.4.pe4]

PERSPECTIVES

Frailty--The Search For Underlying Causes

Jeremy Walston

The author is at the Center on Aging and Health in the Division of Geriatric Medicine and Gerontology at the Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. E-mail: jwalston@jhmi.edu

http://sageke.sciencemag.org/cgi/content/full/2004/4/pe4

Key Words: frailty • weakness • fatigue • inflammation • cytokine IL-6

Abstract: Research into the biological basis of frailty has been difficult to accomplish because of a lack of standardized definitions, disease and disability confounders, and complex multifactorial etiology. Multiple physiological systems are likely to be involved, including the skeletal muscle, endocrine, and immune/inflammation systems. Physiological characterization of frail older adults might provide etiologic clues. Translational research programs that connect mechanisms related to aging, such as oxidative damage and telomere shortening, to clinical aging-related syndromes will be necessary to further this critical area of geriatric research.

Citation: J. Walston, Frailty--The Search For Underlying Causes. Sci. Aging Knowl. Environ. 2004 (4), pe4 (2004).

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Statin Use and Incident Frailty in Women Aged 65 Years or Older: Prospective Findings From the Women's Health Initiative Observational Study.
A. Z. LaCroix, S. L. Gray, A. Aragaki, B. B. Cochrane, A. B. Newman, C. L. Kooperberg, H. Black, J. D. Curb, P. Greenland, and N. F. Woods (2008)
J. Gerontol. A Biol. Sci. Med. Sci. 63, 369-375
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HIV-1 Infection Is Associated With an Earlier Occurrence of a Phenotype Related to Frailty.
L. Desquilbet, L. P. Jacobson, L. P. Fried, J. P. Phair, B. D. Jamieson, M. Holloway, J. B. Margolick, and for the Multicenter AIDS Cohort Study (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 1279-1286
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Insulin Resistance and Inflammation as Precursors of Frailty: The Cardiovascular Health Study.
J. I. Barzilay, C. Blaum, T. Moore, Q. Li Xue, C. H. Hirsch, J. D. Walston, and L. P. Fried (2007)
Arch Intern Med 167, 635-641
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From Bedside to Bench: Research Agenda for Frailty.
L. P. Fried, E. C. Hadley, J. D. Walston, A. B. Newman, J. M. Guralnik, S. Studenski, T. B. Harris, W. B. Ershler, and L. Ferrucci (2005)
Sci. Aging Knowl. Environ. 2005, pe24
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Science of Aging Knowledge Environment. ISSN 1539-6150