Sci. Aging Knowl. Environ., 6 October 2004
Vol. 2004, Issue 40, p. nf90
[DOI: 10.1126/sageke.2004.40.nf90]


Fanning the Flames

Telomerase aggravates oxidative damage in mitochondria

R. John Davenport

Abstract: Some children do their chores at home but throw spitballs at school. Similarly, the enzyme telomerase helps cells by tending to the ends of their chromosomes in the nucleus, but it makes mischief elsewhere. A new study reveals that telomerase makes a second home in mitochondria--the cell's powerhouses--where it enhances damage from oxidants. The work identifies a new location for the enzyme, but further studies are necessary to illuminate how it accelerates decay.

Citation: R. J. Davenport, Fanning the Flames. Sci. Aging Knowl. Environ. 2004 (40), nf90 (2004).

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