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Sci. Aging Knowl. Environ., 20 October 2004 PERSPECTIVESAging-Related Research in the "-omics" AgeMatt Kaeberlein The author is in the Department of Genome Sciences at the University of Washington, Seattle, WA 98195, USA. E-mail: kaeber{at}u.washington.edu http://sageke.sciencemag.org/cgi/content/full/2004/42/pe39Key Words: microarray gene expression profiling biomarker high-throughput screen RNAi calorie restriction
Abstract: The application of high-throughput technologies to aging-related research has the potential to dramatically enhance our understanding of how longevity is determined at a molecular level. Genome-scale studies are being carried out in every major model system used for aging-related research, and new technologies are being developed to rapidly identify mutations or small-molecules that increase life span. A meta-analysis of data derived from genome-wide studies of aging in simple eukaryotes will allow the identification of conserved determinants of longevity that can be tested in mammals. Citation: M. Kaeberlein, Aging-Related Research in the "-omics" Age. Sci. Aging Knowl. Environ. 2004 (42), pe39 (2004).
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Science of Aging Knowledge Environment. ISSN 1539-6150