Sci. Aging Knowl. Environ., 20 October 2004
Vol. 2004, Issue 42, p. pe39
[DOI: 10.1126/sageke.2004.42.pe39]


Aging-Related Research in the "-omics" Age

Matt Kaeberlein

The author is in the Department of Genome Sciences at the University of Washington, Seattle, WA 98195, USA. E-mail: kaeber{at}

Key Words: microarray • gene expression profiling • biomarker • high-throughput screen • RNAi • calorie restriction

Abstract: The application of high-throughput technologies to aging-related research has the potential to dramatically enhance our understanding of how longevity is determined at a molecular level. Genome-scale studies are being carried out in every major model system used for aging-related research, and new technologies are being developed to rapidly identify mutations or small-molecules that increase life span. A meta-analysis of data derived from genome-wide studies of aging in simple eukaryotes will allow the identification of conserved determinants of longevity that can be tested in mammals.

Citation: M. Kaeberlein, Aging-Related Research in the "-omics" Age. Sci. Aging Knowl. Environ. 2004 (42), pe39 (2004).

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