Sci. Aging Knowl. Environ., 20 October 2004
Vol. 2004, Issue 42, p. re7
[DOI: 10.1126/sageke.2004.42.re7]

REVIEWS

Microarrays as a Tool to Investigate the Biology of Aging: A Retrospective and a Look to the Future

Simon Melov, and Alan Hubbard

Simon Melov is at the Buck Institute for Age Research, Novato, CA 94945, USA, and Alan Hubbard is in the Division of Biostatistics at the University of California, Berkeley, Berkeley, CA 94720, USA. E-mail: smelov{at}buckinstitute.org (S.M.)

http://sageke.sciencemag.org/cgi/content/full/2004/42/re7

Key Words: microarray • differential expression • biomarker of aging • statistics

Abstract: The use of microarrays as a tool to investigate fundamental biological questions has become ubiquitous over the past several years. Microarrays are becoming as common as the polymerase chain reaction or any of the other tools in the molecular biologist's armory. Unlike experiments involving other tools, however, the design and analysis of microarray experiments present some unique problems to molecular biologists, problems with which statisticians have long been familiar. In this overview of microarrays and aging-related research, we will review selected highlights of microarray studies that have been carried out to study aging to date, as well as discuss some of the potential problems that routinely arise during these types of experiments, especially in the context of aging.

Citation: S. Melov, A. Hubbard, Microarrays as a Tool to Investigate the Biology of Aging: A Retrospective and a Look to the Future. Sci. Aging Knowl. Environ. 2004 (42), re7 (2004).

Read the Full Text




THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster.
M. Zhan, H. Yamaza, Y. Sun, J. Sinclair, H. Li, and S. Zou (2007)
Genome Res. 17, 1236-1243
   Abstract »    Full Text »    PDF »
Common aging pathways in worms, flies, mice and humans.
S. K. Kim (2007)
J. Exp. Biol. 210, 1607-1612
   Abstract »    Full Text »    PDF »




Science of Aging Knowledge Environment. ISSN 1539-6150