Sci. Aging Knowl. Environ., 27 October 2004
Vol. 2004, Issue 43, p. ns8
[DOI: 10.1126/sageke.2004.43.ns8]

NEWS SYNTHESIS

The Goldilocks Genes

Our chromosomes can get sloppy and delete or pick up genes. Researchers are starting to probe how these DNA miscues affect health and longevity

Mitch Leslie

http://sageke.sciencemag.org/cgi/content/full/2004/43/ns8

Abstract: From cancer biologists to geneticists, scientists are tackling the question of how raising or lowering the number of gene copies from the standard two affects how we live and how soon we die. New genomic studies show that large-scale DNA duplications and deletions are more common than scientists imagined, even in healthy people. Other work demonstrates that our supply of gene copies matters in Parkinson's disease and cancer. The results raise the possibility that how fast we age depends in part on how many duplicates of certain genes we carry.

Citation: M. Leslie, The Goldilocks Genes. Sci. Aging Knowl. Environ. 2004 (43), ns8 (2004).

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