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Sci. Aging Knowl. Environ., 17 November 2004
Vol. 2004, Issue 46, p. nf102
[DOI: 10.1126/sageke.2004.46.nf102]


Ironing Out Cell Death

Metal-grabbing enzyme saves suicidal cells

Mitch Leslie

Abstract: Like a governor giving a pardon, the molecule NF-{kappa}B spares cells condemned to death. New research reveals that the protein delivers its stay of execution by enlisting an iron-absorbing protein, which short-circuits a death-promoting pathway. The work could help researchers devise better treatments for conditions in which cells ignore suicide directives, including cancer and rheumatoid arthritis.

Citation: M. Leslie, Ironing Out Cell Death. Sci. Aging Knowl. Environ. 2004 (46), nf102 (2004).

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