Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Aging Knowl. Environ., 24 November 2004
Vol. 2004, Issue 47, p. re8
[DOI: 10.1126/sageke.2004.47.re8]


Nuclear Hormone Receptors, Metabolism, and Aging: What Goes Around Comes Around

Keith Pardee, Jeff Reinking, and Henry Krause

The authors are in the Banting and Best Department of Medical Research, University of Toronto, Charles H. Best Institute, Toronto, Ontario, Canada. E-mail: h.krause{at} (H.K.)

Key Words: nuclear receptor • hormone • metabolism • circadian rhythm • nitric oxide • heme

Abstract: Previous studies have linked the mysterious and inevitable process of aging to essential processes such as metabolism, maturation, and fecundity. Each of these processes is controlled to a large extent by nuclear hormone receptors (NHRs). NHRs also play important roles in the control of periodical processes, the most recently implicated being circadian rhythm. This Review stresses the mounting evidence for tight relationships between each of these NHR-regulated processes and the processes of aging.

Citation: K. Pardee, J. Reinking, H. Krause, Nuclear Hormone Receptors, Metabolism, and Aging: What Goes Around Comes Around. Sci. Aging Knowl. Environ. 2004 (47), re8 (2004).

Read the Full Text

Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75.
L. Caceres, A. S. Necakov, C. Schwartz, S. Kimber, I. J. H. Roberts, and H. M. Krause (2011)
Genes & Dev. 25, 1476-1485
   Abstract »    Full Text »    PDF »
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?.
E. M. V. de Cavanagh, F. Inserra, and L. Ferder (2011)
Cardiovasc Res 89, 31-40
   Abstract »    Full Text »    PDF »
Dynamic regulation of Drosophila nuclear receptor activity in vivo.
L. Palanker, A. S. Necakov, H. M. Sampson, R. Ni, C. Hu, C. S. Thummel, and H. M. Krause (2006)
Development 133, 3549-3562
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150