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Sci. Aging Knowl. Environ., 24 November 2004 REVIEWSNuclear Hormone Receptors, Metabolism, and Aging: What Goes Around Comes AroundKeith Pardee, Jeff Reinking, and Henry Krause The authors are in the Banting and Best Department of Medical Research, University of Toronto, Charles H. Best Institute, Toronto, Ontario, Canada. E-mail: h.krause{at}utoronto.ca (H.K.) http://sageke.sciencemag.org/cgi/content/full/2004/47/re8Key Words: nuclear receptor • hormone • metabolism • circadian rhythm • nitric oxide • heme
Abstract: Previous studies have linked the mysterious and inevitable process of aging to essential processes such as metabolism, maturation, and fecundity. Each of these processes is controlled to a large extent by nuclear hormone receptors (NHRs). NHRs also play important roles in the control of periodical processes, the most recently implicated being circadian rhythm. This Review stresses the mounting evidence for tight relationships between each of these NHR-regulated processes and the processes of aging. Citation: K. Pardee, J. Reinking, H. Krause, Nuclear Hormone Receptors, Metabolism, and Aging: What Goes Around Comes Around. Sci. Aging Knowl. Environ. 2004 (47), re8 (2004).
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Science of Aging Knowledge Environment. ISSN 1539-6150
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