Sci. Aging Knowl. Environ., 24 November 2004
Vol. 2004, Issue 47, p. re8
[DOI: 10.1126/sageke.2004.47.re8]


Nuclear Hormone Receptors, Metabolism, and Aging: What Goes Around Comes Around

Keith Pardee, Jeff Reinking, and Henry Krause

The authors are in the Banting and Best Department of Medical Research, University of Toronto, Charles H. Best Institute, Toronto, Ontario, Canada. E-mail: h.krause{at} (H.K.)

Key Words: nuclear receptor • hormone • metabolism • circadian rhythm • nitric oxide • heme

Abstract: Previous studies have linked the mysterious and inevitable process of aging to essential processes such as metabolism, maturation, and fecundity. Each of these processes is controlled to a large extent by nuclear hormone receptors (NHRs). NHRs also play important roles in the control of periodical processes, the most recently implicated being circadian rhythm. This Review stresses the mounting evidence for tight relationships between each of these NHR-regulated processes and the processes of aging.

Citation: K. Pardee, J. Reinking, H. Krause, Nuclear Hormone Receptors, Metabolism, and Aging: What Goes Around Comes Around. Sci. Aging Knowl. Environ. 2004 (47), re8 (2004).

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