Sci. Aging Knowl. Environ., 8 December 2004
Vol. 2004, Issue 49, p. re9
[DOI: 10.1126/sageke.2004.49.re9]


Poly(ADP-Ribosyl)ation, PARP, and Aging

Sascha Beneke, and Alexander Bürkle

The authors are in the Molecular Toxicology Group, Department of Biology, Box X911, University of Konstanz, D-78457 Konstanz, Germany. E-mail: alexander.buerkle{at} (A.B.)

Key Words: centrosome • DNA repair • genomic stability • PARP • poly(ADP-ribosyl)ation • telomere

Abstract: Poly(ADP-ribose) polymerases (PARPs) catalyze the poly(ADP-ribosyl)ation of proteins. This posttranslational modification, as generated by the DNA damage-activated enzymes PARP-1 and -2, has long been known to be involved in DNA repair. Correlative data have suggested an association between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity, and this link has recently been strengthened by the discovery of interactions between PARP-1 and the Werner syndrome protein. Emerging additional members of the PARP family display different cellular localizations and are involved in diverse processes such as the regulation of telomere or centrosome function, thereby providing further, independent links between poly(ADP-ribosyl)ation and the aging process.

Citation: S. Beneke, A. Bürkle, Poly(ADP-Ribosyl)ation, PARP, and Aging. Sci. Aging Knowl. Environ. 2004 (49), re9 (2004).

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Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal.
M. Y. Kim, T. Zhang, and W. L. Kraus (2005)
Genes & Dev. 19, 1951-1967
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