Sci. Aging Knowl. Environ., 4 February 2004
Vol. 2004, Issue 5, p. nf15
[DOI: 10.1126/sageke.2004.5.nf15]

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Tugging at Heartstrings

Protein associated with heart abnormalities and premature aging syndrome transmits mechanical stress to the nucleus

R. John Davenport

http://sageke.sciencemag.org/cgi/content/full/2004/5/nf15

Abstract: A runner needs resilient tendons to move joints and withstand impact. Similarly, a cell needs molecular rubber bands to remain supple. A protein whose defective forms trigger several human diseases, including a premature aging syndrome, normally helps cells respond to mechanical stress, according to new studies in mice. The work provides the strongest evidence yet for how alterations in the protein stir up trouble.

Citation: R. J. Davenport, Tugging at Heartstrings. Sci. Aging Knowl. Environ. 2004 (5), nf15 (2004).

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