Sci. Aging Knowl. Environ., 15 December 2004
Vol. 2004, Issue 50, p. nf109
[DOI: 10.1126/sageke.2004.50.nf109]

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Toxic Spill

Parkin protects dopamine cargo within neurons from leaking

Mary Beckman

http://sageke.sciencemag.org/cgi/content/full/2004/50/nf109

Abstract: WASHINGTON, D.C.--Rust can ruin train tracks, causing wrecks that spill toxins. Similarly, a particular insecticide splinters transportation conduits inside motor neurons, derailing containers holding a deadly chemical, according to work presented here 5 December 2004 at the American Society for Cell Biology Annual Meeting. The study also shows that parkin, a protein implicated in Parkinson's disease (PD), helps keep the tracks safe. The results could help researchers understand how PD knocks off only a subset of neurons.

Citation: M. Beckman, Toxic Spill. Sci. Aging Knowl. Environ. 2004 (50), nf109 (2004).

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