Sci. Aging Knowl. Environ., 11 February 2004
Vol. 2004, Issue 6, p. or1


Respect Thy Neighbor!

Derek C. Radisky, and Mina J. Bissell

Abstract: Science 303, 775-777 (2004)

The tissue microenvironment surrounding tumor cells may not be just a passive bystander during tumorigenesis. In their Perspective, Radisky and Bissell discuss new work showing that mice with stromal cells unable to respond to the cytokine TGF-{beta} rapidly develop epithelial tumors (Bhowmick et al.). The Perspective authors explore the implications of the finding that stromal cells are a protective influence on epithelial cells, preventing them from becoming tumorigenic.

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