Sci. Aging Knowl. Environ., 11 February 2004
Respect Thy Neighbor!
Derek C. Radisky, and Mina J. Bissellhttp://sageke.sciencemag.org/cgi/content/abstract/2004/6/or1
Abstract: Science 303, 775-777 (2004)
The tissue microenvironment surrounding tumor cells may not be just a passive bystander during tumorigenesis. In their Perspective, Radisky and Bissell discuss new work showing that mice with stromal cells unable to respond to the cytokine TGF- rapidly develop epithelial tumors (Bhowmick et al.). The Perspective authors explore the implications of the finding that stromal cells are a protective influence on epithelial cells, preventing them from becoming tumorigenic.
Science of Aging Knowledge Environment. ISSN 1539-6150