Sci. Aging Knowl. Environ., 18 February 2004
Vol. 2004, Issue 7, p. pe7
[DOI: 10.1126/sageke.2004.7.pe7]


Impaired Angiogenesis in the Aged

May J. Reed, and Jay M. Edelberg

May J. Reed is in the Department of Medicine in the Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98104, USA. E-mail: mjr{at} Jay M. Edelberg is in the Departments of Medicine and Cell and Developmental Biology at Weill Medical College of Cornell University, New York, NY 10021, USA. E-mail: jme2002{at}

Key Words: vasodilation • coagulation • growth factors • extracellular matrix • wound healing • atherosclerosis

Abstract: The process of angiogenesis, during which new blood vessels are formed, is impaired during aging. This Perspective describes many of the myriad components of the angiogenic response that are altered with age. In addition, the impact of impaired angiogenesis on wound healing, vascular disease, and cancer in the aged is discussed.

Citation: M. J. Reed, J. M. Edelberg, Impaired Angiogenesis in the Aged. Sci. Aging Knowl. Environ. 2004 (7), pe7 (2004).

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