Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Aging Knowl. Environ., 18 February 2004
Vol. 2004, Issue 7, p. pe7
[DOI: 10.1126/sageke.2004.7.pe7]


Impaired Angiogenesis in the Aged

May J. Reed, and Jay M. Edelberg

May J. Reed is in the Department of Medicine in the Division of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA 98104, USA. E-mail: mjr{at} Jay M. Edelberg is in the Departments of Medicine and Cell and Developmental Biology at Weill Medical College of Cornell University, New York, NY 10021, USA. E-mail: jme2002{at}

Key Words: vasodilation • coagulation • growth factors • extracellular matrix • wound healing • atherosclerosis

Abstract: The process of angiogenesis, during which new blood vessels are formed, is impaired during aging. This Perspective describes many of the myriad components of the angiogenic response that are altered with age. In addition, the impact of impaired angiogenesis on wound healing, vascular disease, and cancer in the aged is discussed.

Citation: M. J. Reed, J. M. Edelberg, Impaired Angiogenesis in the Aged. Sci. Aging Knowl. Environ. 2004 (7), pe7 (2004).

Read the Full Text

Aging is associated with impaired angiogenesis, but normal microvascular network structure, in the rat mesentery.
R. S. Sweat, D. C. Sloas, S. A. Stewart, M. Czarny-Ratajczak, M. Baddoo, J. R. Eastwood, A. D. Suarez-Martinez, M. S. Azimi, H. E. Burks, L. O. Chedister, et al. (2017)
Am J Physiol Heart Circ Physiol 312, H275-H284
   Abstract »    Full Text »    PDF »
Prominin-1/CD133 expression as potential tissue-resident vascular endothelial progenitor cells in the pulmonary circulation.
A. Sekine, T. Nishiwaki, R. Nishimura, T. Kawasaki, T. Urushibara, R. Suda, T. Suzuki, S. Takayanagi, J. Terada, S. Sakao, et al. (2016)
Am J Physiol Lung Cell Mol Physiol 310, L1130-L1142
   Abstract »    Full Text »    PDF »
Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors.
L. Katsimpardi, N. K. Litterman, P. A. Schein, C. M. Miller, F. S. Loffredo, G. R. Wojtkiewicz, J. W. Chen, R. T. Lee, A. J. Wagers, and L. L. Rubin (2014)
Science 344, 630-634
   Abstract »    Full Text »    PDF »
Nitrite Anion Therapy Protects Against Chronic Ischemic Tissue Injury in db/db Diabetic Mice in a NO/VEGF-Dependent Manner.
S. C. Bir, C. B. Pattillo, S. Pardue, G. K. Kolluru, X. Shen, T. Giordano, and C. G. Kevil (2014)
Diabetes 63, 270-281
   Abstract »    Full Text »    PDF »
Association Between Advanced Age and Vascular Disease in Different Arterial Territories: A Population Database of Over 3.6 Million Subjects.
N. Savji, C. B. Rockman, A. H. Skolnick, Y. Guo, M. A. Adelman, T. Riles, and J. S. Berger (2013)
JACC 61, 1736-1743
   PDF »
The Intersection Between Aging and Cardiovascular Disease.
B. J. North and D. A. Sinclair (2012)
Circ. Res. 110, 1097-1108
   Abstract »    Full Text »    PDF »
Loss of Bcl-2 During the Senescence Exacerbates the Impaired Angiogenic Functions in Endothelial Cells by Deteriorating the Mitochondrial Redox State.
M. Uraoka, K. Ikeda, R. Kurimoto-Nakano, Y. Nakagawa, M. Koide, Y. Akakabe, Y. Kitamura, T. Ueyama, S. Matoba, H. Yamada, et al. (2011)
Hypertension 58, 254-263
   Abstract »    Full Text »    PDF »
G-CSF for stem cell therapy in acute myocardial infarction: friend or foe?.
W. Shim, A. Mehta, S. Y. Lim, G. Zhang, C. H. Lim, T. Chua, and P. Wong (2011)
Cardiovasc Res 89, 20-30
   Abstract »    Full Text »    PDF »
Ageing and endothelial progenitor cellrelease of proangiogenic cytokines.
E. Kushner, G. Van Guilder, O. MacEneaney, J. Greiner, J. Cech, B. Stauffer, and C. DeSouza (2010)
Age Ageing 39, 268-272
   Full Text »    PDF »
Long-Term Outcome of Therapeutic Neovascularization Using Peripheral Blood Mononuclear Cells for Limb Ischemia.
J. Moriya, T. Minamino, K. Tateno, N. Shimizu, Y. Kuwabara, Y. Sato, Y. Saito, and I. Komuro (2009)
Circ Cardiovasc Interv 2, 245-254
   Abstract »    Full Text »    PDF »
Stem Cells and the Regeneration of the Aging Cardiovascular System.
V. L.T. Ballard and J. M. Edelberg (2007)
Circ. Res. 100, 1116-1127
   Abstract »    Full Text »    PDF »
Vascular Cell Senescence: Contribution to Atherosclerosis.
T. Minamino and I. Komuro (2007)
Circ. Res. 100, 15-26
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science of Aging Knowledge Environment. ISSN 1539-6150